DNA instability in neurons

Like all cells, neuronal tissues accrue DNA damage leading to mutation, cell loss or even cancer. We are applying advanced next generation sequencing technologies to directly measure rates of neuronal genomic instability. This project aims to establish if neurons have a higher innate vulnerability to DNA damage than corresponding non-neuronal cell types. This basic research has significant ramifications for the future detection, treatment and even prevention of paediatric brain cancers.

 

DNA recombination in lymphocytes

The mammalian immune system is capable of producing massive diversity through a process of combinatorial shuffling of a defined and restricted germ line genetic resource. We are applying cutting edge second generation sequencing based analyses to the field of T-Cell Receptor and Immunoglobin VDJ rearrangements in an effort to gain deeper insights into the basic mechanistics of this process. A better understanding of the fundamental processes underlying immune response have significant implications in the fields of immunology and cancer therapy.